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Small molecule legumain inhibitors and probes for imaging of solid tumors and inflammation

Researchers in Prof. Matt Bogyo's laboratory have developed highly selective and potent legumain inhibitors that can be used as fluorescent probes for in vivo imaging. Legumain (also known as asparginyl endopeptidase) is a lysosomal cysteine protease th...
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Preventing immunological rejection of transplanted stem cells

Researchers in Prof. Mark Davis’ and Joseph Wu’s laboratories have developed a novel immunosuppressive cocktail that can prevent rejection and induce immune tolerance towards stem cell transplants. Recently, there has been much interest in using adult...
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