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Novel Aminoglycosides with Reduced Toxicity

The increasing number of resistant strains of bacteria requires the development of new antibiotics and repurposing of existing antibiotics. Aminoglycosides are potent, broad spectrum antibiotics whose use is limited by oto and nephrotoxic side effects, su...
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Structure-based design of IL-17 dominant negative mutants

This invention describes a potential treatment for autoimmune disease and inflammatory conditions with mutant IL-17 molecules. These dominant negative mutants were designed using the newly described crystal structure of IL-17 bound to its receptor. Thes...
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