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Point-sink DNA Shearing Device


Stanford Reference:

95-048


Abstract


Stanford researchers have developed a new method and apparatus for shearing polynucleotides. The device can shear both double (ds)- and single-stranded (ss) polynucleotides and produces a defined size distribution of fragments, with a selected mean size ranging between 200 and 20,000 for ds polynucleotides and half those values for ss polynucleotides. This technology improves upon most current methods for random DNA fragmentation by creating randomly cleaved and efficiently clonable fragments that reproducibly are small in size and fall within a narrow range in size.

Applications


  • Polynucleotide preparation for molecular cloning, sequencing, hybridization

Advantages


  • Simple operation
  • Reproducible
  • Produces small size fragments
  • Requires small sample volume (to 100 microliters)
  • Yields narrow range of fragments (within a factor of 2)

Publications



Innovators & Portfolio



Patent Status



Date Released

 2/5/2014
 

Licensing Contact


Gregg Kyle, Senior Licensing Associate
gregg.kyle@stanford.edu
+1-650-725-3476 (Direct)

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