Stanford researchers at the Zare lab have patented a new mode of operating a time-of-flight mass spectrometer (TOFMS). A continuous ion beam emerging from the ion source is accelerated and then modulated by a pseudorandom sequence of “on” and “off” pulses. This multiplexing scheme increases the ion usage to 50% for a single detector instrument and 100% for a multiple detector instrument, which improves the signal level considerably over that of conventional TOFMS. The gains in signal lead to an improved signal-to-noise ratio or alternatively reduced data acquisition time, giving HT-TOFMS a major instrumental advantage over conventional TOFMS in a number of applications at little additional cost. Related Technologies from the Zare Lab available for license: S00-227
“Bradbury-Nielson gates for modulating beams of charged particles and method of making same” S02-134
"Cockeyed Implementation of Hadamard Transform Time-Of-Flight Mass Spectrometry" S02-141
"Rapid and Accurate Modulation of Ion Beams" S04-238
"Microfabricated beam modulation device" S05-314
"High Time Resolution Bradbury-Nielson Gates"