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Time-of-flight mass spectrometer and ion analysis


Stanford Reference:

97-208


Abstract


Stanford researchers at the Zare lab have patented a new mode of operating a time-of-flight mass spectrometer (TOFMS). A continuous ion beam emerging from the ion source is accelerated and then modulated by a pseudorandom sequence of “on” and “off” pulses. This multiplexing scheme increases the ion usage to 50% for a single detector instrument and 100% for a multiple detector instrument, which improves the signal level considerably over that of conventional TOFMS. The gains in signal lead to an improved signal-to-noise ratio or alternatively reduced data acquisition time, giving HT-TOFMS a major instrumental advantage over conventional TOFMS in a number of applications at little additional cost.

Related Technologies from the Zare Lab available for license:
S00-227 “Bradbury-Nielson gates for modulating beams of charged particles and method of making same”
S02-134 "Cockeyed Implementation of Hadamard Transform Time-Of-Flight Mass Spectrometry"
S02-141 "Rapid and Accurate Modulation of Ion Beams"
S04-238"Microfabricated beam modulation device"
S05-314 "High Time Resolution Bradbury-Nielson Gates"



Applications


  • Mass spectrometry - improved mass analysis of the chemical components in a continuous ion source, such as complex biomolecular mixtures

Advantages


  • High duty cycle of ions (50%) in a continuous stream
  • Improved signal-to-noise ratio or reduced data acquisition time
  • Ability to use full ion stream rather than a portion
  • Real-time mass spectra
  • Inexpensive instrumentation and operation

Publications



Related Web Links



Innovators & Portfolio



Patent Status



Date Released

 10/18/2010
 

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Related Keywords


Bradbury-Nielson Gates   research tool: spectroscopy   Spectroscopy   spectrometer   Mass Spectrometry   Mass Spectrometer   MALDI-TOF MS   instrumentation: spectroscopy   instrumentation: analytical   biochemical analysis   spectral imaging   ion beam   time of flight mass spectrometry   Biological & Chemical Analyzers   chemical analysis   chemical testing   ion source   time-resolved spectroscopy   molecular assay   Compact spectrometer   
 

   

  

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S97-208 Time-of-flight mass spectrometer and ion analysis