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Docket #: S98-097

Mouse Model for Phosphodiesterase (PDE4D) Deficiency

This mouse model of phosphodiesterase deficiency was developed using homologous recombination to knock-out the gene for PDE4D. The mice have a null PDE4D gene on C57BL/6 x 129/OLA background. These mice have proven useful in studies of asthma (see publications). Also, based on the known function of PDE4, these mice would be useful in studying inflammation, female reproduction, and learning and memory.

Publications

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