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Genomic Analysis with Molecular Inversion Probes


Stanford Reference:

00-045


Abstract


Developed by researchers from the Stanford Genome Technology Center, this technology is a patented method for high-throughput quantitative analysis of small but highly specific regions of the genome. Molecular inversion probes (MIPs) allow automated multiplex assays of genomic DNA markers (up to ~10,000 SNPs per assay) with a low likelihood of background error than previous PCR methods. The method can be applied to a variety of detection platforms including DNA arrays, mass spectrometry, and gel electrophoresis. MIPs are now widely used for SNP genotyping, copy number variant analysis, genome wide association studies.

Applications


  • Pharmacogenomics - genotyping of genes important in drug metabolism
  • Molecular diagnostics - genotyping of genes associated with disease
  • Genomic research - genotyping, haplotyping, copy number variant and genome wide association studies to identify genotype-phenotype correlations with disease states

Advantages


  • High throughput - genotypes ~10,000 SNP in a single tube assay
  • High specificity
  • Robust - DNA detection from formalin-fixed paraffin embedded samples and other samples that are prone to DNA degradation

Innovators & Portfolio



Patent Status



Date Released

 5/2/2013
 

Licensing Contact


Linda Chao, Senior Associate
(650) 725-9408 (Direct)
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[-] Map/Timeline

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01-203 Quenched DNA probes that "light up" on sensing genetic sequences
02-017 Integrated Fluorescence Sensor

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Related Keywords


DNA genotyping   SNP detection   genomics: polymorphism   diagnostic: DNA probe   genetic probe   genotyping   genomics: pharmacogenomics   healthcare: microarrays   genomic analysis   genome-wide association studies (GWAS)   molecular inversion probes   targeted resequencing   variant detection   nucleic acid detection   
 

   

  

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00-127 Hybridization for High Throughput Genotyping
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S00-045 Genomic Analysis with Molecular Inversion Probes