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Artificial Corneal Implant


Stanford Reference:

04-194


Abstract


Artificial corneal implants (keratoprosthesis) have great potential to benefit millions in the U.S. and worldwide with corneal disease. Nearly 10 million people worldwide are blind due to corneal disease and current corneal implants have not been adopted because of complications such as infection and peripheral tissue necrosis. Stanford University scientists developed a novel corneal prosthesis based on an interpenetrating double network hydrogel of poly(ethylene glycol) (PEG) and poly(acrylic acid) (PAA). Both PEG and PAA are biocompatible and are used widely in ophthalmic, biomedical, and commercial applications. The hydrogel has high mechanical strength (estimated to be 1.1 MPa) in the context of high water content (~80%), while possesing a Dk value of 90. This indicates that the membrane will be easy to implant and durable, while possessing the ability to facilitate high permeability of oxygen and nutrients to pass through the hydrogel.

The scientists also developed a method for the fabrication of the full-thickness artificial using this hydrogel. This fabrication is done in a sequential manner without the need for fusion or gluing of two separate core and skirt pieces. The present device overcomes the limitations of many other devices due to dissimilar material properties, weakness at the core-skirt junction, or general weakness of the skirt itself. The core-and-skirt construct consists of a optically clear central component and a porous periphery with pores sized for host tissue integration, i.e. to adhere and enable migration of stromal cells. Collagen can be covalently linked to the surface of the artificial cornea to promote adhesion, proliferation, and migration on cells over the surface of the prosthesis for full integration into the eye. This technology could be a practical alternative to current methods for replacing diseased corneas.


Applications


  • Production of a corneal prosthesis for treatment of corneal replacement

Advantages


  • A high degree of ocular tolerance
  • Biocompatibility
  • Mechanical strength
  • Ease of implantation
  • Elimination of transmittable infectious diseases from human donor corneal implants
  • Better management of post-operative inflammation and infection
  • Implant is resistant to opacification

Publications



Innovators & Portfolio



Patent Status



Date Released

 10/15/2012
 

Licensing Contact


Irit Gal, Senior Licensing Associate
650-723-1586 (Business)
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Related Keywords


medical devices: prosthetics/rehabilitation   ophthalmology   Cornea   artificial cornea   corneal implant   Corneal prosthesis   
 

   

  

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