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A Novel Process to Create Lipid Bilayer Membranes on Gold & TiO2 Solid Supports


Stanford Reference:

05-115


Abstract


Stanford University scientists have developed a novel method to create lipid bilayer membranes on a variety of surfaces, including gold and titanium-oxide (TiO2). This technology uses amphipathic α-helical peptides to penetrate, destabilize, and rupture the outer leaflet of intact vesicles, thereby fusing the vesicles into planar bilayers on preferred solid substrates. Previously, supported lipid bilayers were limited to silicon oxide or organic film-modified surfaces. With this invention, researchers have the flexibility to capitalize on the advantages of other substrates, such as the favorable electrical properties of gold or the beneficial biocompatibility TiO2. This technology can be used for a wide range of membrane-associated biological, physiological, or electrochemical applications.

Related Technology
The inventors have developed a related technology that uses amphipathic a-helical peptides as an antiviral agent for prevention and disinfection (see Stanford Docket S07-204).

Applications


  • Biosensors
  • Medical implants
  • Catalytic interfaces
  • Optoelectronic devices
  • Lab-on-a-chip devices

Advantages


  • Favorable substrate properties - this method allows for utilization of the favorable electrical properties of gold and the beneficial biocompatibility of TiO2 in the production of novel lipid bilayer membranes
  • Fast and easy - the invention reduces the time and labor involved to make complete planar bilayers

Publications



Innovators & Portfolio



Patent Status



Date Released

 8/4/2010
 

Licensing Contact


Gregg Kyle, Senior Licensing Associate
gregg.kyle@stanford.edu
+1-650-725-3476 (Direct)

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Related Keywords


Lipid bilayer membrane   biochip   biosensor   healthcare: biochip   implant   membranes   substrates   healthcare   iFarm   
 

   

  

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S05-115 A Novel Process to Create Lipid Bilayer Membranes on Gold & TiO2 Solid Supports