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Interpenetrating Polymer Network Hydrogel Corneal Prosthesis


Stanford Reference:

06-309


Abstract


A multidisciplinary team of Stanford University inventors have developed a unique interpenetrating double network hydrogel with surfaces that can be chemically modified to allow binding of biomolecules. The material has high mechanical strength in the context of high water content. For medical applications, these features make the hydrogel easy to implant, durable, and permeable to oxygen and nutrients.

The inventors have fabricated a full-thickness artificial cornea (keratoprosthesis) using this material. The technology overcomes the limitations of many other devices which have structural weaknesses due to dissimilar material properties. In addition, collagen can be covalently linked to the surface of the artificial cornea to promote full integration into the eye. In addition to corneal transplantation, the invention has the potential to revolutionize the refractive surgical industry by reversibly mimicking the effects of either LASIK (Laser In Situ Keratomileusis) or PRK (Photorefractive Keratectomy) without the need for tissue ablation.

Stage of Research
The inventors have shown that these hydrogels are biocompatible in an animal model.

Ongoing Research
Continuing research entails further characterization of double network properties and the cellular response to them both in vitro and in vivo.



Applications


  • Corneal implants
    • for transplantation
    • for refractive surgery alternative (e.g. LASIK or PRK) – without tissue ablation

Advantages


  • High mechanical strength - 1.0 MPa - 10 MPa
  • High oxygen permeability - Dk value is as high as 95 barrers
  • High water content - 70% - 90%
  • High transparency - 70% or more
  • Corneal implant advantages:
    • enhanced tissue integration
    • high nutrient permeability to support adherent cells
    • epithelialization
    • resistant to protein absorption

Publications



Related Web Links



Innovators & Portfolio



Patent Status



Date Released

 9/5/2014
 

Licensing Contact


Irit Gal, Senior Licensing Associate
650-723-1586 (Business)
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Related Keywords


ophthalmology   materials: polymer   medical devices: prosthetics/rehabilitation   Corneal prosthesis   artificial cornea   cornea   corneal implant   
 

   

  

Also of Interest...
97-042 OptoBondTM - Hydroxide and Silicate Bonding
99-046 Electroactive Polymers for Opto-Electronic Devices
99-171 Dual Purpose Electroactive Copolymers

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