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Anti-Pbx3a Monoclonal Antibody


Stanford Reference:

01-245D


Abstract


Researchers in the laboratory of Dr. Michael Cleary at Stanford University have developed anti-Pbx3a monoclonal antibodies to study transcriptional regulation and embryonic development. Pbx proteins comprise a set of four TALE (three amino acid loop extension) class homeodomain transcription factors that are implicated in developmental gene expression. They form hetero-oligomeric DNA-binding complexes and function as transcriptional regulators in cells of different developmental lineages.

Pbx3 is expressed in high levels predominantly in the developing central nervous system, including a region of the medulla oblongata that is implicated in the control of respiration. Pbx3-deficient mice die within a few hours of birth from central respiratory failure and provide a model for congential central hypoventiliation syndrome. Pbx3 encodes the alternatively spliced Pbx3a and Pbx3b isoform proteins. Pbx3a is the high molecular-weight protein form. In mouse embryogenesis, it has been localized to various tissues of the central and peripheral nervous systems as well as in chondrocytes through the skeleton. The anti-Pbx3a antibodies could be used in research related to central nervous system, respiratory, and skeletal development.


Applications


  • Research related to:
    • embryonic development (particularly in the central nervous system, skeleton, and respiratory system)
    • transcriptional regulation

Publications



Web Site


Cleary Lab

Innovators & Portfolio



Date Released

 4/21/2015
 

Licensing Contact


Brenda Martino, Biological Materials Specialist
(650) 725-9119 (Direct)
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Related Keywords


transcription factors   CNS   respiratory   research tool   research tool: antibody   research tool: cell line   
 

   

  

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