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Docket #: S10-203

Monoclonal antibody against human HGAL antigen

Stanford researchers have developed a monoclonal antibody for diagnosis, prognosis, classification, and research of B-cell derived lymphomas. This is a mouse antibody directed against the human HGAL antigen (human germinal center-associate lymphoma, a cytoplasmic protein expressed in germinal center B cells). The HGAL protein is expressed in certain types of non-Hodgkin lymphomas and is associated with a better prognosis.

Applications

  • Diagnostic - identification and classification of B-cell derived lymphoma subtypes
  • Prognostic marker for diffuse large B cell lymphoma and Hodgkin lymphoma
  • Research - the antibody can be used for western and immunoprecipitation and utilized for studies of HGAL function

Advantages

  • Specific - an excellent marker for differentiation of FL from other low grade lymphomas

Publications

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