Researchers in Prof. Jennifer Cochran’s laboratory have engineered stable, microbially-expressed protein fragments that are comparable to hepatocyte growth factor (HGF) in agonistic activity for the Met receptor. These fragments are a homodimerized version of the N-domain and first kringle domain of HGF that have been specifically designed for thermal stability and high expression yields in yeast. In addition, they contain a heparin-binding epitope for easy attachment and incorporation into a variety of biomaterials. These molecules have a great potential for a variety of tissue engineering and regenerative medicine applications.Ongoing Research
The inventors continue to characterize the biological efficacy of these engineered proteins.