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Potent MET receptor agonists and antagonists


Stanford Reference:

10-337


Abstract


Researchers in the Cochran lab have engineered MET receptor (HGFR) agonists with enhanced stability, ease of production and comparable agonistic activity to wild type HGF. Various groups have demonstrated that MET agonism has therapeutic effects in neurodegenerative diseases such as Alzheimer’s and ALS, in stroke, in myocardial infarction, and in pulmonary fibrosis.

Ongoing Research
The inventors are exploring the therapeutic efficacy of this protein in various animal disease models, including models of myocardial infarction.

Applications


  • Therapeutic for:
    • Neurodegenerative diseases
    • Myocardial infarction
    • Stroke
    • Pulmonary Fibrosis
  • Stem cell and tissue engineering

Advantages


  • Potent - agonistic activity similar to full-length HGF
  • Stable
  • High recombinant yield in yeast
  • Can incorporate into biomaterials using a heparin-binding epitope

Publications



Related Web Links



Innovators & Portfolio



Date Released

 6/12/2012
 

Licensing Contact


Ximena Ares, Licensing Associate
650-724-0960 (Direct)
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[-] Map/Timeline

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Related Keywords


therapeutic: proteins   hepatic   cardiac tissue   hepatocyte   hepatocyte growth factor   muscular dystrophies   myocardial infarction   regenerative medicine   tissue engineering   tissue regeneration   tissue repair   therapeutic   neurodegeneration   fibrosis   
 

   

  

Also of Interest...
87-057 Endothelial Molecules and the Control of Leukocyte Extravasation - MECA-79 and MECA-367
92-045 Novel Endothelial Adhesion Molecule for Monocytes: L11-CD43
92-146 Achieving B-Cell Lymphoma Growth Modulation and Enhanced Tumor Resistance Using Idiotype/Cytokine Conjugates

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S10-337 Potent MET receptor agonists and antagonists