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Potent Met receptor agonists and antagonists


Stanford Reference:

10-337


Abstract


Researchers in Prof. Jennifer Cochran’s laboratory have engineered stable, microbially-expressed protein fragments that are comparable to hepatocyte growth factor (HGF) in agonistic activity for the Met receptor. These fragments are a homodimerized version of the N-domain and first kringle domain of HGF that have been specifically designed for thermal stability and high expression yields in yeast. In addition, they contain a heparin-binding epitope for easy attachment and incorporation into a variety of biomaterials. These molecules have a great potential for a variety of tissue engineering and regenerative medicine applications.

Ongoing Research
The inventors continue to characterize the biological efficacy of these engineered proteins.

Applications


  • Stem cell and tissue engineering, such as:
    • wound healing
    • cardiac, liver, and renal engineering
    • treatment of diseases such as myocardial infarction and muscular dystrophy

Advantages


  • Potent - agonistic activity similar to full-length HGF
  • Stable
  • High recombinant yield in yeast
  • Can incorporate into biomaterials using a heparin-binding epitope

Publications



Related Web Links



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Date Released

 6/12/2012
 

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Ximena Ares, Licensing Associate
650-724-0960 (Direct)
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[-] Map/Timeline

87-057 Endothelial Molecules and the Control of Leukocyte Extravasation - MECA-79 and MECA-367
92-045 Novel Endothelial Adhesion Molecule for Monocytes: L11-CD43
92-146 Achieving B-Cell Lymphoma Growth Modulation and Enhanced Tumor Resistance Using Idiotype/Cytokine Conjugates

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Related Keywords


therapeutic: proteins   therapeutic: wound healing   hepatic   cardiac tissue   hepatocyte   hepatocyte growth factor   muscular dystrophies   myocardial infarction   regenerative medicine   tissue engineering   tissue regeneration   tissue repair   wound healing   therapeutic   
 

   

  

Also of Interest...
87-057 Endothelial Molecules and the Control of Leukocyte Extravasation - MECA-79 and MECA-367
92-045 Novel Endothelial Adhesion Molecule for Monocytes: L11-CD43
92-146 Achieving B-Cell Lymphoma Growth Modulation and Enhanced Tumor Resistance Using Idiotype/Cytokine Conjugates

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S10-337 Potent Met receptor agonists and antagonists