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Genetic Variants Associated with Risk for Depression


Stanford Reference:

11-200


Abstract


This technology is a panel of SNP (single nucleotype polymorphism) markers that are significantly more common in patients with major depression than in healthy patients. The variants are found in genes related to the cortisol stress response – corticotropin releasing hormone receptors (CRHR1 and 2) and the glucocorticoid receptor (GR). Genotyping with these markers could help identify patients at risk for depression, select patients for specific anti-depressant treatment, or determine inclusion criteria in clinical trials.

Stage of Research
The inventors studied 40 patients with psychotic major depression, 26 patients with non-psychotic major depression and 29 healthy controls. They found GR and CRHR1 genotypes that contributed significantly to psychosis measures and CRHR1 contributed significantly to depression severity rating.

Applications


  • Genetic screening - risk assessment for patients with depression symptoms or family history
  • Personalized medicine - genotyping to select anti-depressant therapy
  • Clinical trials - genotyping to determine inclusion criteria for patients in clinical trials

Publications



Innovators & Portfolio



Date Released

 12/3/2013
 

Licensing Contact


Sara Nakashima, Licensing Associate
650 725 9115 (Direct)
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Related Keywords


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