Notice: Undefined index: HTTP_ACCEPT_LANGUAGE in C:\inetpub\wwwroot\technology_detail.php on line 331
 Technology Detail


The Office of Technology Licensing was established in 1970 to transfer technologies developed at Stanford. Find out more about OTL's history, mission, staff, and statistics.

Login to TechFinder » 

Device to Control and Monitor Cardiac Excitability


Stanford Reference:

11-259


Abstract


Stanford engineers have developed an all-electric pacing device that can stimulate or inhibit cardiac tissue while simultaneously recording its effects on the stimulated cells. This provides unprecedented ability to monitor the tissue in real-time, enabling detection of activity without blanking periods, and true closed-loop controlled stimulation. The device affords precise spatial and temporal control with beat-by-beat adjustments for improved safety and reliability. The technology is compatible with current stimulation delivery tools (microelectrode arrays, leads, catheters). Its applications include research, drug-screening, arrhythmia models, pacemaker devices and RF ablation guidance.

Stage of Research
-In vitro - in cardiomyocyte studies, the inventors used high-frequency stimulation and recorded depolarization events on the same electrode during the stimulus, enabling strength-duration relationship measurements and beat-to-beat stimulation threshold monitoring following pacing onset or pharmacological modulation. They also demonstrated the inhibition of excitation through prolonged high-frequency stimulation, and the generation of reversible conduction blocks.

-In vivo – the inventors are conducting studies of the device in large animal models.


Applications


  • In vitro electrophysiology - creation of reproducible conduction patterns for the study of cardiac conduction and cardiac arrhythmias (e.g., atrial fibrillation) in cultures, slices or explants
  • Cell-based drug screening assays - reproducible in vitro re-entry model for the identification of drugs affecting cardiac electrophysiology (e.g. modulating susceptibility to re-entry)
  • Pacemakers with in vivo closed-loop pacing - power optimized stimulation for pacemakers using measurement of tissue response to adjust stimulus in real-time, on a beat-by-beat basis
  • Radio-frequency ablation guidance - the impact of a conduction block under the catheter before permanently scaring the tissue

Advantages


  • Simultaneous stimulation and recording on the same electrode
  • Real-time feedback and monitoring:
    • for pacemaker applications – feedback on stimulation effectiveness
    • for drug screening applications – monitoring stimulation threshold changes such as modulation by pharmacological agents
  • Precise control - reversible, precise spatial and temporal control of conduction block (without alteration of the tissue or cellular structure)
  • Improved safety and reliability - lower electrode potentials reduces electrochemical reaction at electrodes, hence increases safety and reliability, especially for long-term use
  • Compatibility - all-electric technology compatible with standard electrophysiology delivery systems
  • Sustained conduction block - tested up to five minutes in cardiomyocyte cultures

Publications



Demonstration of Device on Cardiomyocyte Culture


Left: Illustration of high-frequency stimulation (a), and demonstration of simultaneous stimulation and recording of evoked depolarization of HL-1 cardiomyocytes, on the same electrode. Right: Calcium imaging of a depolarization wave in an HL-1 cardiomyocyte culture with an inhibitory stimulus applied to a ‘fence’ electrode (depicted by the dashed lines in the top panel): top – before application of the stimulus; middle – during inhibition; bottom – after the stimulus has been stopped. Note the wave wrapping around the inhibited block (and lack of depolarization inside), and the return to a normal propagation once the stimulus is stopped (adapted from Dura et al., PLoS ONE 7(4): e36217. doi:10.1371/journal.pone.0036217).

Real Time Video of Cardiomyocyte Excitability Inhibition


Innovators & Portfolio



Patent Status



Date Released

 9/10/2014
 

Licensing Contact


Mona Wan, Associate Director
650-498-0902 (Business)
Login to Request Information

[-] Map/Timeline

91-041 NF-AT transcription system for screening of immunosuppressive drugs•The Fgl-5 cell line
95-040 Green Fluorescent Protein (GFP) Mutants
95-115 Novel fluorescent probe Cy7-APC

more technologies »

Related Keywords


cardiac pacing   atrial arrhythmia   Cardiac resynchronization   atrial fibrillation   arrhythmia   cardiac ablation   ablation   electrophysiology   MEMS: bioMEMS   microelectrode array   cardiac rhythm management   cardiac tissue   cardiovascular device   electrical stimulation   medical devices: cardiovascular   models of medical pathophysiology   screening: cellular assay   11-259   cardiomyocyte   catheter ablation   pacemakers   radiofrequency ablation   ventricular pacing   electrophysiologic monitoring   adaptive cardiac stimulation   defibrillator   
 

   

  

Also of Interest...
91-041 NF-AT transcription system for screening of immunosuppressive drugs•The Fgl-5 cell line
95-040 Green Fluorescent Protein (GFP) Mutants
95-115 Novel fluorescent probe Cy7-APC

Recently Viewed...
S11-259 Device to Control and Monitor Cardiac Excitability