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Novel Receptor Mediates mTOR Amino Acid Signaling


Stanford Reference:

11-397


Abstract


Researchers in Professor Tobias Meyer’s laboratory have discovered a novel G-protein coupled receptor (GPCR) that is a potential therapeutic target for cancer and aging related diseases. This receptor controls signaling through the amino acid sensing pathway and is upstream of the known pathway component mTOR. Regulation of the receptor may allow more specific control of mTOR mediated signaling, and its inactivation may have beneficial effects in cancer therapy and in the treatment of neurodegenerative diseases.

Stage of Research
The researchers have localized the protein to the lysosome and have demonstrated that this novel receptor is necessary and sufficient to mediate signaling in the amino acid sensing pathway.

Ongoing Research
The Meyer lab continues to define the role of this novel receptor in the amino acid sensing pathway.

This technology has been funded by the Stanford SPARK program, part of the School of Medicine.


Applications


  • Therapeutic target:
    • Use in high throughput screening assays
    • For cancer or neurodegenerative diseases
    • For diabetes or obesity

Advantages


  • Specific:
    • Provides a target for regulating lysosomal mTOR activity
    • Upstream regulator of the amino acid sensing pathway

Related Web Links



Innovators & Portfolio



Date Released

 8/20/2012
 

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Ximena Ares, Licensing Associate
650-724-0960 (Direct)
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Related Keywords


target   rapamycin   GPCR targeted therapeutics   screening: target   top pharma companies   therapeutic: cell signalling   therapeutic: anticancer   GPCR   drug target   Neurodegenerative diseases   mTOR   G protein-coupled receptors   aging   age-related disorders   signaling enzymes   
 

   

  

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