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Flagellin As An Immunostimulant


Stanford Reference:

12-172


Abstract


Researchers in Dr. James Swartz’s lab have developed a flagellin array that stimulates stronger and more rapid immune response. Vaccines may be helpful in preventing or treating a variety of diseases; however there are times when it is difficult for a vaccine to generate an effective immune response. This may be due to the inability to deliver an antigen in a manner that renders it immunogenic. Bacterial flagellins have been explored as potential vaccine adjuvants. This technology provides a flagellin array that strongly activates the innate immune system to increase the efficiency, strength and speed of the immune response to vaccines.

Stage of Research
The inventors have developed a flagellin array and its bioactivity has been assessed.


Applications


  • Vaccines
    • Prophylactic
    • Therapeutic

Advantages


  • Greater stimulation of target cells
  • Stronger, more rapid immune response
  • Allows smaller vaccine doses
  • Potential for use in depot type slow delivery formulations
  • Flagellin display entity can be readily modified and optimized
  • Stimulant can be used on same particle as antigen or co-administered with antigen

Publications



Related Web Links



Innovators & Portfolio



Patent Status



Date Released

 3/25/2013
 

Licensing Contact


Mary Albertson, Senior Licensing Associate
(650) 725-9411 (Direct)

Online Non-Disclosure Agreement (NDA)





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Related Keywords


adjuvant   adjuvant, vaccine, VLP   cancer vaccine   foldon, trimer, influenza vaccine   influenza vaccine   prophylactic:vaccine   therapeutic: vaccine   vaccines   vaccine response   Virus-like particles (VLPs)   
 

   

  

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