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Compartmentalized integrated biochips


Stanford Reference:

12-293


Abstract


Sensor arrays for molecular detection are often desired to contain large numbers of individual sensors. In principle, every sensor can be used to detect a different target analyte, but chemical and biological cross reactivity and different dynamic ranges reduce the marginal benefit of each additional sensor of the array. One approach to overcome these deficiencies is the compartmentalization of the sensor array into individual sensors.

Stanford researchers have developed a method of forming compartmentalization of a sensor array chip at the interface with a microfluidic chip. The microfluidic device can be fabricated separately and attached to the sensor array chip after surface functionalization. This allows the use of sensor arrays with compartments of varying sizes that match their intended use.

Figures

Figure 1: Photograph of microfluidic chips, with sensor solid support and holder/connectors


Stage of Research:
Prototypes demonstrated effective microfluidic sample multiplexing for solid state sensor arrays without modification on the sensor chip.


Applications


  • Compartmentalized biosensors for analytical biochemistry, diagnostics and immunoassays
  • Diagnostic devices
  • Lab-on-a-chip type of devices that use multiple solid state sensors on a single chip/substrate

Advantages


  • Compartmentalized
  • Multiplexed use of the sensor, so that one sensor array can be used for multiple experiments and/or with different reagents and/or samples.
  • Eliminates the detection cross reactivity - separate detection of 2 species which show cross reactivity in detection processes into different compartments.
  • Tunable - allows for individual adjustment of the dynamic range of each sensor group. The reactions can be grouped to similar dynamic ranges and each group's sensors' dynamic range can be individually controlled (e.g. by dilution of the reaction species).
  • Fabricated from current manufacturing methods - Can be individually fabricated from the microfluidic chip in preferred manufacturing processes.
  • The sensor surface can be functionalized (e.g. by a robotic spotter) before the microfluidic chip is combined with the sensor.
  • Enables integrated biochip - In addition to microfluidic components, logic and/or actuation on chip, sample preparation and dilution stages, and samples and reagents routing to the sensor interface can be included in the microfluidic chip.

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Innovators & Portfolio



Date Released

 11/14/2012
 

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Related Keywords


sensors: biosensor   research tool: equipment   research tool: antibody   diagnostic: point-of-care   diagnostic: marker   diagnostic: immunoassay   diagnostic: elisa   diagnostic: DNA probe   diagnostic: detection   MEMS: microfluidics   diagnostic: biochip   genomics: RNA   diagnostic: autoimmunity   genomics: proteomics   genomics: DNA   medical devices: diagnostics & measurement   diagnostic: assay   diagnostic: antibody   bioassay   immunoassay   lab-on-a-chip   microfluidic device   microfluidics   
 

   

  

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