Notice: Undefined index: HTTP_ACCEPT_LANGUAGE in C:\inetpub\wwwroot\technology_detail.php on line 331
 Technology Detail


The Office of Technology Licensing was established in 1970 to transfer technologies developed at Stanford. Find out more about OTL's history, mission, staff, and statistics.

Login to TechFinder » 

Selective modulation of anxiety features


Stanford Reference:

13-095


Abstract


Researchers in Dr. Karl Deisseroth’s lab have developed a selective approach to treat anxiety. Anxiety is characterized by several features that are coordinately regulated by diverse neuronal system outputs. These features range from behavioural choice patterns, such as risk avoidance, to changes in physiology exemplified by respiratory rate alterations. A major limiting step in the treatment of anxiety is the inability to selectively control the various features of the disease. For instance, some features may not be that troubling whereas others, such as elevated respiratory rate, may be debilitating or life threatening. It would be of great value to be able to individually regulate the various disease features. This technology describes a new role for the bed nucleus of the stria terminalis (BNST) in the coordinated modulation of diverse anxiety features and provides methods to selectively tune these features.

Stage of research
The inventors have demonstrated that distinct BNST subregions exert opposite effects in modulating anxiety and define separable anxiolytic roles for different anterodorsal BNST projections.

Ongoing research
Additional work in mapping anxiety circuitry.


Applications


  • Treatment of anxiety- including selective regulation of the various disease features.
  • Development of research tools to screen new anxiety therapeutics.

Advantages


  • Precise
  • Specific-could allow selective regulation of different anxiety features.

Publications



Related Web Links



Innovators & Portfolio



Date Released

 12/9/2013
 

Licensing Contact


Evan Elder, Licensing Associate
650-725-9558 (Mobile)
Request Info

[-] Map/Timeline

83-145 T-Cell Antibody Panel: CD 2,3,4,5,7,8
95-040 Green Fluorescent Protein (GFP) Mutants
96-113 Semiconductor Light Emitting Devices for Phototherapy of Jaundiced Newborns or Circadian Rhythm Disorders

more technologies »

Related Keywords


neuromodulation device   research tool: reagent   neurological diseases   psychiatric   anxiety   behavior   behavior change interventions   induced neuronal cells   nerve monitoring   neuro monitoring   neurobehavioral intervention   neurobiology   neurostimulation   neuromodulation   neuronal circuits   Neuropsychiatric disease   optogenetics   therapeutic medical devices   
 

   

  

Also of Interest...
83-145 T-Cell Antibody Panel: CD 2,3,4,5,7,8
95-040 Green Fluorescent Protein (GFP) Mutants
96-113 Semiconductor Light Emitting Devices for Phototherapy of Jaundiced Newborns or Circadian Rhythm Disorders

Recently Viewed...
S13-095 Selective modulation of anxiety features