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Implant coating to improve osseointegration


Stanford Reference:

13-124


Abstract


Researchers in Dr. Sarah Heilshorn’s lab have developed a protein coating that can be applied directly to bone-interfacing implants to promote osseointegration. Bone-interfacing implants have many applications including; orthopedic, dental, spinal and cochlear devices. These implants can loosen due to poor integration into the bone and fail. Current solutions to reduce implant failure are not optimal as they do not facilitate active bone regeneration, instead relying on porous regions that passively allow bone in-growth or space-filling adhesives. This technology overcomes this limitation as it provides a coating that directs bone regeneration on the implant surface thereby improving the bone-implant interface.

Stage of Research
Initial in vitro proof-of-concept studies have shown feasibility of this coating.

Ongoing Research
Continued work to further demonstrate the functionality and advantages of the coating. In vivo studies to demonstrate efficacy in small animal models.


Applications


  • Coating for any bone-interfacing medical device including:
    • Hip and knee prostheses
    • Dental implants
    • Spinal implants
    • Cochlear implants
    • Bone screws

Advantages


  • Stable
  • Easily scalable coating production
  • Cytocompatible
  • Improved cell adhesion and mineralization on implant surface
  • Can be used for synthetic, inorganic, or metallic surfaces
  • Can be applied to implant directly after fabrication
  • No operating room preparation of coating is needed
  • Maintains shape, size and feel of current implants
  • No additional training required for the surgeon
  • Customizable- can include biologics to further improve functionality

Publications



Related Web Links



Innovators & Portfolio



Date Released

 6/26/2013
 

Licensing Contact


Irit Gal, Senior Licensing Associate
650-723-1586 (Business)
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Related Keywords


materials: polymer   bioengineering   biomaterials   bone engineering   bone regeneration   bone repair   cell adhesion   implantable devices   surgical implants   tissue engineering   tissue regeneration   bone growth   cochlear implant   regenerative medicine   Hip Replacement   joint replacement   knee replacement   medical device: orthopedics   orthopaedic reconstruction   orthopedic instruments   orthopedic surgery   Spinal surgery   
 

   

  

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S13-124 Implant coating to improve osseointegration