Researchers in Dr. Sarah Heilshorn’s lab have developed a protein coating that can be applied directly to bone-interfacing implants to promote osseointegration. Bone-interfacing implants have many applications including; orthopedic, dental, spinal and cochlear devices. These implants can loosen due to poor integration into the bone and fail. Current solutions to reduce implant failure are not optimal as they do not facilitate active bone regeneration, instead relying on porous regions that passively allow bone in-growth or space-filling adhesives. This technology overcomes this limitation as it provides a coating that directs bone regeneration on the implant surface thereby improving the bone-implant interface.Stage of Research
Initial in vitro
proof-of-concept studies have shown feasibility of this coating.Ongoing Research
Continued work to further demonstrate the functionality and advantages of the coating. In vivo
studies to demonstrate efficacy in small animal models.