Markers for the Detection of Human Embryo Developmental Quality

Stanford researchers have developed methods for genetic and epigenetic diagnosis of embryos to determine those of which are more likely to be chromosomally normal and advance in development. This assessment method allows selection of healthier embryos for implantation. IVF procedures can be improved by allowing for early transfer of fewer, high quality embryos. These parameters can be used to select the optimal embryos for transfer, cryo-preservation, or for additional pre-implantation genetic diagnosis (PGD) analysis during an IVF procedure.

Figure

Figure description - Summary model of epigenetic regulation during pre-implantation development. Embryonic development was monitored in both mouse and human embryos by imaging analysis from the zygote to the blastocyst stage. Addition of certain growth factors to embryo culture media can prevent alterations in epigenetic profiles and improve developmental competence of patient embryos subject to culture. Publication link is below.

Stage of Research

Proof-of-concept – Findings demonstrate epigenetic mechanisms have essential roles for pre-implantation development and possible pregnancy outcomes, especially in the context of IVF