Anti-mouse TIM-1 mAb 3B3

Dr. Rosemarie DeKruyff and colleagues have generated an agonistic TIM-1 monoclonal antibody (mAb), called TIM-1 mAb 3B3. TIM-1 plays critical roles in regulating immune cell activity and is also involved in allergic response and asthma. To better understand how TIM-1 functions in the immune system the inventors generated the 3B3 mAb. It is a rat IgG2a mAb and can be used for research to study the surface expression and function of TIM-1.

Stage of research
The inventors have shown the 3B3 antibody is specific for TIM-1 and have used it in a variety of in vitro and in vivo studies to investigate TIM-1 function.