Docket #: S15-282
Probes for mycobacterium detection
This invention describes the designing of biochemical probes for acid-fast bacteria detection. This probe will measure the presence of acid-fast bacteria in a biological matrix.
Stage of the Research:
Preliminary proof-of-concept demonstration has been achieved.
Ongoing Research:
Further validation and testing with more complex biological samples including clinical samples.
Clinical trials are being planned.
Applications
- Clinical diagnosis of microbial diseases.
Advantages
- Simple assay workflow
- Relatively fast staining
- Potential for good sensitivity
- Potentially compatible with existing clinical microbiology instrumentation
Publications
- Cheng, Y. et al. Rapid and specific labeling of single live Mycobacterium tuberculosis with a dual-targeting fluorogenic probe Sci. Transl. Med. 10 eaar44 15 August 2018.
- U.S. Patent Application Serial No. 15/001,591
Patents
- Published Application: 20170044593
- Published Application: WO2017027062
- Issued: 10,370,538 (USA)
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