Dual-modality Imaging Probe for Combined Localization and Apoptosis Detection of Stem Cells

Researchers at Stanford have developed a ferumoxytol-based dual-modality imaging probe that allows for long-term stem cell tracking through MRI and early diagnosis of cell apoptosis through simultaneous fluorescence imaging. Stem cell transplants have great promise for therapeutic use. However a large portion of the transplanted stem cells undergo apoptosis and are cleared from the transplant site. The inability to recognize this apoptosis at an early stage is an obstacle for long term success of stem cell transplants. To overcome this challenge, the inventors have designed and synthesized a ferumoxytol-based dual-modality imaging probe. The probe allows simultaneous monitoring of the localization and viability of transplanted stem cells. This technology enables stem cells to be visualized and monitored directly, non-invasively and longitudinally to improve the success of stem cell transplants.

Stage of research
Validation studies are ongoing and show great promise.