Stanford engineers have developed a patented device and sample preparation technique for high throughput purification, concentration, and sample preparation of a wide variety of biomolecules.
FragFEATURE is a data-driven computational method for fragment binding prediction. It predicts small molecule fragments preferred by a protein structure using a knowledge base of all previously observed protein-fragment interactions.
Druggability of a protein is its potential to be modulated by drug-like molecules. It is important in the target selection phase. We developed DrugFEATURE to quantify druggability by assessing the microenvironments in potential small-molecule binding sites.
Stanford researchers have identified small molecules that can intercept cancerous or pre-cancerous cells by activating DNA repair in cells damaged by oxidative stress.
The patched gene is a component of the so-called Hedgehog signaling pathway that is known to be involved in the commonest human cancer, basal cell carcinoma, and in brain cancer.
Stanford researchers have invented a system for identifying head impacts and rejecting spurious motion events. The system has been implemented in an instrumented mouthguard which measures head kinematics on the sports field.
Dr. Brian Zabel and Prof. Eugene Butcher have developed rat monoclonal antibodies (clones BZ2E3 and BZ5B8, rIgG2aκ isotype) to the mouse chemokine (CC motif) receptor-like 2 (CCRL2) protein.
Precision in surgical removal of cancer is guided by pathological assessment of resected tissues, and there is a dire need to reduce the time and distance between the critical diagnostic events and the surgical procedure.
Researchers in Prof. Paul Khavari's laboratory have discovered a novel compound and method to block invasive neoplasia without effects on normal cells.
Dr. Andrea Meredith and Dr. Richard Aldrich have generated a viable mouse knockout KCNMA1, the gene encodes the pore-forming subunit of the BK large conductance calcium-activated potassium channel (also called KCa1.1, SLO1, and MaxiK).
Researchers in Dr. Mark Davis' lab have developed a patented method to perform multi-parametric phenotypic analysis and T cell receptor (TCR) sequencing from single sorted T cells.
This invention is a system that allows labeling of radiological images based on anatomy, such that radiologists or other users can locate the images using anatomical names.
Researchers from Dr. Mark Kay's laboratory at Stanford University have merged desirable qualities of multiple natural AAV isolates by an adapted DNA family shuffling technology to create a complex library of hybrid capsids from eight different wild-type viruses.