Type 1 regulatory T cells (Tr1s) are an inducible subtype of regulatory T cells that can play a beneficial (autoimmune diseases, allergy, hematological malignancies) or detrimental role (some solid tumors and infectious diseases) in human diseases. Tr1 cells.
Researchers at Stanford have created human induced pluripotent stem cells (hiPSCs) derived from adult human dermal fibroblasts exposed to an environmental factor.
Cell culture is a central technique used for a plethora of research applications including in the modeling of complex diseases, creating transgenic animals, gene therapy, cell therapy, regenerating lost tissue, and organ biogenesis.
Mature pancreatic islets are the gold standard for transplantation-based approaches for islet replacement in type 1 and type 3c diabetes mellitus (T1D and T3cD), but this feature is offset by the scarcity of human cadaveric pancreas donors.
Mouse embryonic stem (ES) cells are used for generating knockout and knockin mouse models, which are crucial for biomedical research as well as pre-clinical studies.
Stanford inventors have identified a treatment regimen that allows expansion of cardiomyocytes (CMs) derived from human induced pluripotent stem cells in vitro.
Researchers in Dr. Karl Deisseroth's laboratory at Stanford University have developed a novel suite of genetically-encodable, optically-activated modulators of second messengers (such as cAMP and IP3).
Researchers in Prof. Gerald Crabtree's laboratory have produced a mouse allowing high-throughput screening for activity and inhibition of virtually any chromatin modifier in any murine tissue.
Stanford researchers have developed an R-spondin1-producing cell line. The cell line is a transfectant of 293T cells expressing mouse R-spondin1 protein tagged with N-terminus HA and C-terminus Fc.
Stanford researchers have developed a cell line (MFB-F11) that can be used for an easy, sensitive, and specific bioassay to study the biological functions of Transforming Growth Factor-beta (TGF-beta).