The Longaker lab at Stanford University has recently discovered that local injection of the drug Verteporfin after wounding can reduce scarring, improve the strength of healed skin, and regrow the hair follicles and sweat glands that are usually lost during the scarring proces
Skin wounds invariably heal by developing fibrotic scar tissue, which can result in devastating disfigurement, growth restriction and permanent functional loss.
Wound healing is a huge clinical problem. Problematic outcomes of skin wounds can range from under-healing (e.g., chronic/non-healing wounds) to over-healing (e.g., scarring).
A team of Stanford engineers has identified first-in-class epidermal growth factor (EGF) mutants with enhanced activity. These mutants can stimulate increased EGF receptor activation at 10-fold lower concentrations than wild-type EGF.
Stanford inventors have developed a method of using CRISPR/Cas9 or similar gene editing technologies to genetically edit an individual's own myeloid cells for specific gene targets, which are critical to wound repair, and applying these edited cells in a hydrogel to promote ra
Stanford researchers have designed hydrogels that can be delivered to surgical sites in a patient's body for controlled and sustained release of bacteriophages to treat or prevent bacterial infections.
Proliferative vitreoretinopathy (PVR) is a rare ocular condition that can lead to vision loss or blindness and is a complication of rhegmatogenous retinal detachment, severe diabetic retinopathy, and other conditions.
A team of researchers at Stanford have developed a hydrogel that delivers a scar-reducing focal adhesion kinase inhibitor (FAK-I) to skin grafts and donor sites.
Radiation therapy is a common option in diseases like breast cancer, but can also cause significant damage to the skin. Permanent scarring and fibrosis can result, with both aesthetic and functional consequences for cancer patients.
A team of Stanford researchers has developed a precisely controlled hydrogel drug delivery system that prevents scarring and promotes wound healing in large, full thickness wounds.
Stanford researchers have developed an injectable, biocompatible hydrogel consisting of extracellular matrix (ECM) from human cadaveric tendons as a potential scaffold for guided tissue regeneration and tissue engineering purposes.
Researchers at Stanford have developed methods using click chemistry to immobilize and concentrate therapeutic factors on a tissue to improve wound healing.
Researchers at Stanford have developed methods to enhance bone healing in diabetic patients, who often suffer from impaired fracture healing due to a deficiency in hedgehog signaling in their skeletal stem cells.
Researchers in Prof. Hemamala Karunadasa's laboratory have developed inexpensive, robust, high capacity hybrid materials for reversible or irreversible capture of halogens (chlorine, bromine, and iodine gas).