Multiomic Microsampling using a single drop of blood

Stanford researchers at the Snyder Lab have developed a method for simultaneously measuring thousands of proteins, lipids, and metabolites from home-collected 10 ?L blood samples in conjunction with wearable sensors.

The tracking of blood-based molecules has the potential to generate rich mechanistic insight into diseases and identify novel biomarkers, but frequent collection and profiling is currently difficult because of the requirement for an in-clinic blood draw. Stanford scientists have overcome this limitation with the development of a multiomic microsampling method that enables the measurement of lipid, protein, and metabolite biomarkers at home from a single drop of blood. This method generates rich biological data at frequent timepoints, allowing for the measurement of dynamic molecular response to a dietary or drug intervention. By pairing these sampling and measurement technologies with wearable sensors, the method can also predict molecular changes using physiological measurements from wearable devices.

Stanford News 1/19/23 – "Stanford Medicine researchers measure thousands of molecules from a single drop of blood"

Stage of Development
Proof of concept