16p11.2 deletion mice - Jackson Labs stock no. 025330

Our researcher has developed a mouse model of 16p11.2 deletion syndrome. A copy number variation on human chromosome 16p11.2 is among the most common genetic variations found in autism spectrum disorders. 16p11flx mice are a Cre or FLP recombinase-inducible mouse model of 16p11.2 deletion that has several loxP and frt sites flanking the corresponding 440 kbp region on mouse chromosome 7F3. These mice may be useful in studying basal ganglia circuitry and the pathophysiology of autism.. Several papers using these mice have been published. The mice were also deposited at JAX and are available for use by academic and industrial groups, stock no. 025330