Scalable and low-cost profiling of single-cell gene expression - uses composite probe measurements to profile single-cell gene expression Scalable and low-cost gene-editing system - enables genome-scale CRISPR editing in human cells …
Personalized, patient-specific targeting Higher Quality of Life (QoL) outcomes due to higher efficacy and less side effects Automated, less resource intensive Datta, AnDatta, Anjali; Loo Kung, Gustavo Chau; Barbosa, Daniel; Quah, Kristen; Purger, …
Brand new approach Can increase resistance to immunosuppression and improve potency of existing cancer immunotherapies against solid tumors Dorota D. Klysz, Crystal L. Mackall, et al.. " Inosine Induces Stemness Features in CAR T cells and Enhances …
Easy method implementation Improved anti-tumor potency of CAR-T cells Improved persistence of CAR-T cells in vivo Improved efficacy of immune checkpoint blockade and adoptive T cell therapies Dorota D. Klysz, Steven A. Feldman, Crystal L. Mackall, …
Low-toxicity applicable to live tissues applicable to in vivo tissues and organs Optical/Tissue clearing of turbid biological tissues Optical/Tissue clearing of live tissues Optical/Tissue clearing of in vivo tissues Researchers in the Brongersma …
New class of TG2 inhibitors Bifunctional molecules capable of intracellular delivery of any agent that can be linked to a peptide Elise Loppinet, et. al. " LRP-1 links post-translational modifications to efficient presentation of celiac …
Exploring a mutational space which is multiple orders of magnitude larger than is possible with in vivo evolutionary trajectories. The computational portion of this approach takes seconds, whereas traditional methods employed by the state-of-the-art …
These compounds have potentially less psychoactive or addictive effects when compared to currently available opioid medication. More specifically, target receptors involved in pain modulation, reducing off-target effects. Novel therapeutic avenues …
Full protein expression is not necessary, only binding site sequences are produced on beads. MRBLES use of lanthanides allows for a greater possible coding space given that they have narrow and well-separated emission spectra Multiplexed drug …
Organoid profiling is not restricted to bulk averages for parameters such as growth rates or division times. Does not require specialized instrumentation and is therefore an easy addition to existing cell culture workflows. Organoids can be …
Peptides can be directly synthesized on MRBLES resulting in small reaction volumes and minimal reagent waste. Easily adaptable to other kinase assays. Hein, J.B., Nguyen, H.T., Garvanska, D., Nasa, I., Feng, Y., Lopez-Mendez, B., Davey, N.E., …
Hypoallergenic and immunogenic properties prevent graft-versus-host disease More cost effective and readily available compared to autologous-based anti-cancer vaccines Quality-controlled and regulated Cancer vaccine for high-risk groups Combination …
First antibiotics adjuvant to synergize with antimicrobial peptoids No need to discover new chemical scaffolds since it is an adjuvant Effective against both Gram-positive and Gram-negative bacteria Antibiotic Often, antimicrobial peptoid is not …
Increases safety Novel and portable - first discrete and wearable device to assess fatigue Real-time assessment - headset contains memory storage and processor circuit to provide instant feedback to alert the subject, awaken the subject, or …