Docket #: S01-245D
Anti-Pbx3a Monoclonal Antibody
Researchers in the laboratory of Dr. Michael Cleary at Stanford University have developed anti-Pbx3a monoclonal antibodies to study transcriptional regulation and embryonic development. Pbx proteins comprise a set of four TALE (three amino acid loop extension) class homeodomain transcription factors that are implicated in developmental gene expression. They form hetero-oligomeric DNA-binding complexes and function as transcriptional regulators in cells of different developmental lineages.
Pbx3 is expressed in high levels predominantly in the developing central nervous system, including a region of the medulla oblongata that is implicated in the control of respiration. Pbx3-deficient mice die within a few hours of birth from central respiratory failure and provide a model for congential central hypoventiliation syndrome. Pbx3 encodes the alternatively spliced Pbx3a and Pbx3b isoform proteins. Pbx3a is the high molecular-weight protein form. In mouse embryogenesis, it has been localized to various tissues of the central and peripheral nervous systems as well as in chondrocytes through the skeleton. The anti-Pbx3a antibodies could be used in research related to central nervous system, respiratory, and skeletal development.
Applications
- Research related to:
- embryonic development (particularly in the central nervous system, skeleton, and respiratory system)
- transcriptional regulation
Publications
- Rhee JW, Arata A, Selleri L, Jacobs Y, Arata S, Onimaru H, Cleary ML. "Pbx3 deficiency results in central hypoventilation." Am J Pathol. 2004 Oct;165(4):1343-50.
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