AntiPbx2 monoclonal antibody

Researchers in the laboratory of Dr. Michael Cleary at Stanford University have developed anti-Pbx2 monoclonal antibodies to study transcriptional regulation, embryonic development, and tissue homeostasis. Pbx2 is one of four mammalian genes that encode closely related TALE (three amino acid loop extension) homeodomain proteins that serve as binding partners for a subset of Hox to function as transcriptional regulators in numerous cell types. Pbx2 is widely expressed during mouse embryonic development, particularly in neural and epithelial tissues during late gestation. In postnatal bone marrow and thymus, Pbx2 is the predominant high-molecular-weight isoform Pbx protein. The anti-Pbx2 antibodies could be used in research related to embryonic development and hematopoiesis.