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Docket #: S18-188

Biodegradable and Flexible Arterial Pulse Sensors for the Wireless Monitoring of Blood Flow

Stanford researchers at the Zhenan Bao Lab have designed a device and method for real-time monitoring of arterial blood flow using a biodegradable, flexible, wireless and battery-free sensor mounted on an artery. Monitoring blood flow after vascular anastomosis (surgically connecting blood vessels) is critical to patient recovery and patient outcomes after complex reconstructive surgeries.

This sensor can be operated wirelessly through inductive coupling, has minimal hysteresis, fast response times, excellent cycling stability, is highly robust, and eliminates the need for removal, thus reducing the risk of vessel trauma. A prototype was successfully tested with a custom-made artificial artery model and in vivo in rats. The team believes this is the first demonstration of a wireless, biodegradable sensor that can monitor blood flow in an artery in real-time.

Stanford News Article: January 8, 2019
"Stanford researchers create a wireless, battery-free, biodegradable blood flow sensor"

Figure

Figure description - Biodegradable, flexible and passive arterial-pulse sensor design

Stage of Research

  • In vitro studies with custom-made artificial artery model
  • In vivo studies demonstrating biocompatibility and function in rat model
  • Applications

    • Post-operative monitoring of blood flow after surgical procedures that require vessel anastomosis, which include cardiac, vascular, transplant and reconstructive operations

    Advantages

    • Biodegradable sensor with biocompatible materials, thus eliminates need for removal
    • Real time, continuous blood flow monitoring post-surgery
    • Wireless and battery-free
    • Simple fabrication process
    • Two operating modes:
      • Can measure the blood flow both in contact (pressure sensing) and
      • non-contact (fringe-field sensing) modes
    • Can replace other costly, complex and wired methods such as
      • External Doppler evaluation
      • Visual assessment of skin color and turgor
      • Wired implantable Doppler system
      • Cuff-type Hall-effect sensor for pulse-monitoring
      • Color duplex sonography
      • Near infrared spectroscopy

    Publications

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