Coupling of Excitation and Neurogenesis in Neural Stem/Progenitor Cells

Applications

• Potential therapies for patients with neurological and psychiatric disorders
• Screening methods to identify compounds that induce neurogenesis in culture models
• In vitro screening methods to identify compounds that act directly on excitation sensors or that influence downstream markers

Advantages

• Promotes formation of neurons, and synapse formation in addition to the other influences exerted by typical differentiation medium
• Patient-specific

Publications

• Published patent application no. US-2005-0267011-A2
• K. Deisseroth, R. Malenka. GABA Excitation in the Adult Brain: A Mechanism for Excitation- Neurogenesis Coupling. Neuron 2005, Volume 47, Issue 6, Pages 775-777.
• K. Deisseroth, S. Singla, H. Toda, M. Monje, T. Palmer, R. Malenka. Excitation-Neurogenesis Coupling in Adult Neural Stem/Progenitor Cells. Neuron 2004, Volume 42, Issue 4, Pages 535-552.

Patents

• Published Application: 20050267011
• Issued: 7,670,838 (USA)