Docket #: S19-089
Focused Ultrasound to enhance function and engraftment of pancreatic islets following transplantation
Stanford researchers have demonstrated the application of pulsed Focused Ultrasound (pFUS), to non-invasively enhance the function and engraftment of pancreatic islets following transplantation. Given a significant number of islets are lost immediately after transplantation, pFUS has the potential to be used as a novel therapy to facilitate islet function (i.e. increase insulin secretion) and enhance the engraftment by facilitating islet revascularization and reducing inflammation.
In addition to islet transplantation, this new non-invasive and drug free approach can hold great promise in treating various pancreatic diseases include pancreatitis, pancreatic cancer and diabetes.
Figure
Figure description - Schematic representation of how pFUS can stimulate insulin secretion from ?-cells within pancreatic islets : pFUS enhances insulin secretion by enhancing intracellular calcium levels within ?-cells which then triggers the release of insulin granules via exocytosis.
Stage of Development
Applications
- Islet transplantation for patients with diabetes, pancreatitis, and pancreatic cancer
- Modulating islet biology within the native pancreas (potentially used in the treatment of pancreatic diseases including diabetes, pancreatitis, pancreatic cancer)
Advantages
- Non-invasive and drug-free therapy
- Applies a new technology (pFUS) to a new area (pancreas)
- Targeted – does not impact surrounding healthy tissue
- Focused – can be used to target specific sites within the body
- Tunable – can use lower or higher dose to control molecular activity in the pancreas
Publications
- Razavi, Mehdi, Fengyang Zheng, Arsenii Telichko, Jing Wang, Gang Ren, Jeremy Dahl, and Avnesh S. Thakor. Improving the function and engraftment of transplanted pancreatic islets Using pulsed focused Ultrasound therapy Scientific reports 9, no. 1 (2019): 1-12.
- Razavi, Mehdi, Fengyang Zheng, Arsenii Telichko, Mujib Ullah, Jeremy Dahl, and Avnesh S. Thakor Effect of Pulsed Focused Ultrasound on the Native Pancreas Ultrasound in Medicine & Biology 46, no. 3 (2020): 630-638.
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