LSRE-1 Hybridoma - MEL-14

This antibody(MEL-14) is specific for a single class of lymphocyte surface molecules that appear to mediate recognition of lymph node high endothelial venules and that appear to be required for lymphocyte homing to lymph nodes in vivo.

Reference: Journal of Cellular Biochemistry 30:121-131 (1986)

Rat IgG antibodies against epitopes 1 and 2 of HCAM (CD44) cell adhesion molecule. Involved in Lymphocyte interactions with high endothelial venules during lymphocyte homing and serves as an hylouronate-binding molecule thought to be involved in migration of leukocytes through tissue spaces.

Clone: Hermes-1, Hermes-2

Specificity: Epitopes 1 and 2 of HCAM (CD44) cell adhesion molecule.

Antigen Distribution: HCAM (CD44), a widespread cell adhesion molecule related to cartilage link protein and proteoglycan core proteins. Expressed on the surface of a wide variety of cells. Participates in cell-cell and cell-substrate interactions in the lyphoid, nervous and other systems.