Multiplexed Nanophotonic Microarray Biosensor

The Dionne group has developed a new optical platform for rapid, label-free, high throughput, and multiplexed biomarker analysis. This platform detects multiple distinct DNA sequences, RNA sequences, and different proteins without any fluorescent or optical tagging on a single chip. The sensor consists of a nanostructured optical metasurface and camera sensor. The metasurface is bioprinted with receptor molecules corresponding to the desired biomarkers. Upon binding, the amount of light scattering is altered, which is then capture by the camera sensor. With a surface density exceeding 1 M elements/cm² and easily distinguished pixels, this biosensor captures a range of information from a single test. Applicable to multiple biomarkers for a single sample, or a single biomarker for multiple samples, this system has higher throughput and faster results without the added cost of sample preparation reagents.

Stage of Research