Docket #: S15-080
A Photosynthetic System for Treatment of Ischemic Tissue
Stanford researchers have designed a photosynthetic system powered by a cyanobacterium in solution that can easily be delivered to tissue that lack blood flow (tissue ischemia). This represents a major clinical problem that affects an immense patient population suffering from heart and/or peripheral vascular disease. When a patient presents with evidence of tissue ischemia, this photosynthetic solution can be delivered directly to the tissue at risk, thereby supplying the tissue with glucose and oxygen while removing carbon dioxide. Essentially, this enables light to fuel the tissue rather than blood.
This low cost, simple solution can be used to treat myocardial ischemia and myocardial infarction as well as provide myocardial protection during cardiopulmonary bypass surgery and preserve organs during transportation.
Figure
Figure description - Photosynthetic system
Stage of Research:
On-going Research:
Improving delivery device for enhanced clinical translatability
Applications
- Treatment of myocardial ischemia
- Myocardial protection during cardiopulmonary bypass
- Organ preservation for transplantation
- Treatment of acute and chronic peripheral vascular disease
Advantages
- Low cost relative to stent placement and/or open surgery
- Direct oxygen delivery to muscle at risk without necessarily addressing restoration of blood flow
- Can supply tissue with energy even in patients that otherwise cannot be revascularized either surgically or with stent placement
- Can extend the time that an organ could be transported prior to transplantation, thereby increasing the available patient pool and enhancing outcomes following transplantation
- Could provide a superior treatment for peripheral vascular disease. Specifically, distal revascularization (below the knee) demonstrates modest results at best, whereas this treatment offers a completely novel and potentially superior approach.
Publications
- AATS 2015 Annual Meeting Seattle, WA. USA “Creation of a Novel Endosymbiotic System for Photon Powered Myocardium in the Ischemic Heart”
- Goldstone, Andrew B., Jeffrey E. Cohen, Yasuhiro Shudo, Amanda N. Steele, Michael S. Hopkins, Jay B. Patel, Bryan B. Edwards et al. "A Light-powered Symbiosis With a Primordial Chloroplast Attenuates Myocardial Injury in the Absence of Blood Perfusion." Circulation 132, no. Suppl 3 (2015): A16907-A16907.
Related Links
Patents
- Published Application: 20160310547
- Issued: 10,137,158 (USA)
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