There is broad potential to modulate RNA using small molecules, replacing more costly and difficult-to-administer oligonucleotide therapies. However, methods for screening for such small molecules are lacking.
Stanford researchers have developed a new phospho-responsive system to control protein secretion and surface expression of any tagged protein of interest. The invention enables complex control of multiple proteins.
Researchers at Stanford have created ligand-induced dimerization activating RNA editing (LIDAR), a versatile molecular sensor that turns the presence of a ligand into translation of an output protein.