Stanford researchers have developed one of the smallest, active translational enhancers that can be adapted to control gene regulation. The translation enhancer is a short RNA stem-loop structure isolated from a Hox gene.
Stanford researchers have found a solution to enhance mRNA translation and stability by harnessing SARS-CoV2 genomic sequences themselves. They discovered that the SARS-CoV2 5' untranslated region (5' UTR) can be repurposed for increased translation and stability of any mRNA.
RNA replication and amplification have broad applications across biomedicine, but current methods are limited by a reliance on inefficient, multi-step protocols.
Stanford researchers have developed a new class of materials that enable new strategies for the efficient delivery of messenger RNA (mRNA) into cells and animals. The delivery materials are easily prepared (2 steps), stable and readily tuned.
Stanford inventors from Professor Rhiju Das's lab have developed a method to optimize nucleic acids, including aptamers and messenger RNAs to be more effective in clinical settings.
Researchers in Dr. James Swartz's lab have developed foldon domains that can be used to stabilize protein trimers even under stressful conditions that would otherwise disassemble the trimeric structure.
Stanford researchers have developed a method that not only detects B- and T-cell cancers but also is sufficiently sensitive to detect residual cancer in patients.