Cancers including breast, lung, colon and prostate account for almost ten million deaths worldwide every year. The main cause of cancer deaths is metastasis, which is the propensity of cancer cells to spread throughout the body.
Eat1 and Eat2 are monoclonal antibodies (mAbs) which specifically recognize mouse CD81. It is shown that Eat1 binds to the large extracellular loop (EC2), while Eat2 requires the presence of both extracellular loops for binding.