Stanford scientists have discovered multiple functionally biased ligands that can selectively activate distinct subsets of signaling pathways downstream of the complement 5a receptor.
Stanford researchers have developed a high-affinity IL-11 decoy cytokine for super-agonism and antagonism of the IL-11 receptor, enabling the treatment of a wide variety of diseases from inflammatory disease to cancer as well as research into IL-11 signaling pathways.
Researchers at Stanford have identified a novel class of ribonucleic acid (RNA)-reactive groups that effectively modify the RNA by placing heteroaryl and aryl groups at the 2'-hydroxyl (OH) positions.
Stanford researchers have engineered yeast strains for de novo biosynthesis of tetrahydropapaverine (THP) and a semi-synthetic production of papaverine with high efficiency.
Researchers at Stanford have developed a rapid and efficient method for high-throughput genome editing using CRISPR/Cas9. The CRISPR/Cas9 system allows researchers to edit any site in an organism's genome.
Researchers at Stanford have developed a probe, NIRDye812, which improves contrast between healthy and diseased tissues for fluorescence-guided cancer surgery applications.
Researchers at Stanford have developed a method using expressed genetic barcodes to enable simultaneous lineage tracing and single cell profiling. Intratumor heterogeneity fosters tumor evolution which is a key contributor to therapeutic failure and the lethality of cancer.
Researchers at Stanford have developed the SNAIL-RCA method for inexpensive and efficient multiplexed detection of single RNA molecules in single cells.
Researchers in the Appel lab have developed hydrogels for tumor inoculation that improve precision and statistical power in preclinical mouse models of cancer.
Tracking in vivo cell distribution, migration, and engraftment using conventional techniques including MRI, PET/CT and conventional optical imaging is often hindered by low resolution, radioactive risks, and limited tissue penetration depth.
Researchers at Stanford have developed chemically defined, polyvinyl alcohol (PVA)-based media for culturing hematopoietic stem cells and immune cells (e.g., T cells).
Researchers at Stanford have developed methods for controlling CRISPR-based gene editing and gene regulation. CRISPR systems have been developed for gene editing and gene expression regulation in both prokaryotic and eukaryotic organisms.