Stanford researchers have developed a framework describing an end-to-end approach that infers experimental properties directly from nucleic acid sequence, using a principled statistical mechanical representation of the structure ensemble.
mRNA_hotfix is heuristic approach to adapt a stabilized mRNA to code for a protein mutation variant substitutes mutated codons with codons that maintain low predicted degradation.
Stanford inventors from Professor Rhiju Das's lab have developed a method to optimize nucleic acids, including aptamers and messenger RNAs to be more effective in clinical settings.