Cancers including breast, lung, colon and prostate account for almost ten million deaths worldwide every year. The main cause of cancer deaths is metastasis, which is the propensity of cancer cells to spread throughout the body.
5A6 is monoclonal antibody (mAbs) which recognizes human CD81. It was identified by its ability to induce a reversible antiproliferative effect on a human lymphoma B cell line. This mAbs is capable of inducing signal signal transduction and cell adhesion.
Soluble CD81 molecules were constructed for the purpose of identifying a postulated ligand to CD81. Recently CD81 has been claimed by others to be a candidate for a receptor for the human hepatitis C virus (HCV).
Researchers in Dr. Shoshana Levy's lab have created a pro B cell lines that provides the first B cell lineage tumors in a C57BL mouse strain. The cell lines, known as H11 and 2F3, were made by transducing mouse bone marrow with BCR-ABL retrovirus.
Eat1 and Eat2 are monoclonal antibodies (mAbs) which specifically recognize mouse CD81. It is shown that Eat1 binds to the large extracellular loop (EC2), while Eat2 requires the presence of both extracellular loops for binding.