Researchers at Stanford have developed a method for targeted purification of megabase-sized extrachromosomal DNA (ecDNA) by combining in vitro nuclease treatment and pulsed field gel electrophoresis.
ChiRP (“Chromatin Isolation through RNA Purification”) is a patented RNA “interactomics” technique developed in Prof. Howard Chang's laboratory to capture and identify DNA, RNA or protein molecules that interact with any RNA of interest in a cell.
Researchers in the laboratories of Dr. Eric Kool and Dr. Howard Chang have created and characterized chemical probes that enable accurate RNA structural analysis in living cells. RNA structure plays an important role in practically every facet of gene regulation.