S08-348 Bistable Neural State Switches Researchers in the laboratories of Dr. Karl Deisseroth and Dr. Peter Hegemann have engineered mutant ChR2 (Channelrhodopsin-2) proteins with light-sensitivity that is increased by orders of magnitude compared to wild-type ChR2. Karl Deisseroth Ofer Yizhar Lisa Gunaydin Peter Hegemann Andre Berndt