S20-427 Proliferative vitreoretinopathy (PVR) therapy with growth and differentiation factor 15 (GDF15) Proliferative vitreoretinopathy (PVR) is a rare ocular condition that can lead to vision loss or blindness and is a complication of rhegmatogenous retinal detachment, severe diabetic retinopathy, and other conditions. Jeffrey Goldberg Kun-Che Chang