Engineering novel proteins through directed evolution have become a foundation of protein engineering in biotech. However, these techniques are incapable of simultaneous engineering of protein-protein pairs through library-on-library selections.
Many applications in cell therapy, synthetic biology, and gene therapy require extensive cell engineering, often with multiple vectors due to limitations in packaging capacity.
Stanford University researchers have developed aptamer-antibody chimeras that achieve dynamic, sensitive, and specific biomolecule sensing beyond the capacity of antibodies or aptamers alone.