Researchers in the laboratory of Michael Cleary at Stanford University have developed a mouse that lacks the transcription factor Pbx1. Pbx1 is a proto-oncogene that was originally discovered at the site of chromosomal translocations in pediatric acute leukemia.
Myers, et al previously discovered that specific loss-of-function mutations in the human cystatin B gene on chromosome 21 cause the human genetic disease Progressive Myoclonus Epilepsy (EPM1).