The invention consists of a plasmid encoding enhanced green fluorescent
protein (GFP) modified with a short targeting sequence appended to its
carboxyterminus. This targeting sequence converts the normally stable
Researchers in the laboratory of Dr. Michael Cleary at Stanford University have developed anti-Meis monoclonal antibodies to study transcriptional regulation, embryonic development, and tissue homeostasis.
The general purposes of this invention are 1) to provide bulk quantities of relatively pure soluble antigens of the human major histocompatibility complex; and 2) to determine whether or not soluble forms of the normally surface-bound HLA antigens could be used for diagnostic
The invention consists of the ability to treat inflammatory and autoimmune disorders, particularly but not exclusively those involving mucosal sites such as in the chronic inflammatory bowel disease, by blocking or altering 4B7 interactions with vascular and extracellular matr
Rab proteins represent a large family of ras-like GTPases that regulate distinct vesicular transport events at the level of membrane targeting and/or fusion.
Wnt genes provide important signals dugin development and tumorigenesis, but their mechanism of action is poorly understood. We have developed a novel cell culture assay for the Drosophila Wnt gene wingless, using a Drosophila imaginal disc cell line.
MES-SA is a human uterine sarcoma cell line derived in 1980 from a surgical tumor specimen obtained at the time of hysterectomy from a 56 year old Caucasian female.
The multiple drug resistant variant, MES-SA/Dx5, was established from the human uterine sarcoma cell line, MES-SA, which were grown in the presence of increasing concentrations of doxorubicin.
This mouse model of phosphodiesterase deficiency was developed using homologous recombination to knock-out the gene for PDE4D. The mice have a null PDE4D gene on C57BL/6 x 129/OLA background. These mice have proven useful in studies of asthma (see publications).
This mouse model of phosphodiesterase deficiency was developed using homologous recombination to knock-out the gene for PDE4B. The mice have a null PDE4B gene on C57BL/6 x 129/OLA background.
The Nolan laboratory has created second-generation retrovirus producer lines, termed Phoenix, for the generation of helper free ecotropic and amphotropic retroviruses.
The FELIX vector system, like the PHOENIX MLV-based packaging system, produces high-titre retroviral particles capable of stably transducing a wide variety of target cells with a gene of interest.