Scientists from the Davis and Mackall labs at Stanford have discovered T cell receptor molecules targeting a novel antigen upregulated in cancer. This discovery has potential value for cancer-targeting therapies, particularly CAR T therapies.
Scientists from the Davis and Mackall labs at Stanford have discovered T cell receptor molecules targeting a novel antigen upregulated in cancer. This discovery has potential value for cancer-targeting therapies, particularly CAR T therapies.
Researchers at Stanford have identified polymorphisms in SIRPalpha that can be used to predict responsiveness to immunotherapy. Cancer cells can evade elimination by the immune system by expressing the CD47 "don't eat me" signal.
Researchers in the Sunwoo Lab have developed a method to differentiate intra-epithelial innate lymphoid cells type 1 (ieILC1s) from conventional peripheral natural kills cells for immunotherapeutic purposes.
Researchers at Stanford have developed chimeric antigen receptors (CARs) that target glypican-2 (GPC2) and can be used to treat solid tumors. CAR-engineered T cells have shown great promise as cancer therapeutics.
Stanford inventors have developed a mesenchymal stem cell-based gene therapy that can target the inflammatory environment and secrete immunomodulatory cytokines. The model has been demonstrated in bone marrow mesenchymal stem cells in vitro.
Researchers at Stanford have developed methods to classify and treat MYC-driven hematopoietic cancers. The MYC oncogene drives the proliferation and survival of many hematopoietic cancers. These cancers are highly aggressive and do not respond to conventional chemotherapies.
Stanford researchers have developed a method that can tune the ratio between reversible (RE) and irreversible (IRE) electroporation through waveform adjustments.
5A6 is monoclonal antibody (mAbs) which recognizes human CD81. It was identified by its ability to induce a reversible antiproliferative effect on a human lymphoma B cell line. This mAbs is capable of inducing signal signal transduction and cell adhesion.