S23-393 Using human cathepsins as therapeutic degraders of pathological mucins Stanford scientists have discovered that a subset of human cathepsins can degrade cancer-associated mucins. Carolyn Bertozzi Kayvon Pedram Gabrielle Tender Angel Kuo
S21-461 Cell-type specific enzymatic degradation of pathological mucins Targeted protein degradation is an emerging strategy for the elimination of classically undruggable proteins. Mucins are known to be involved in tumor-progressive pathways but are difficult to target using small molecules and antibodies. Carolyn Bertozzi Kayvon Pedram Dayeon Shon Gabrielle Tender